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10 Years at GSC (Genomic Sciences Center)

Structural determination of the LeuRS-tRNALeu complex
for the genetic code table

Leucyl-tRNA synthetase (LeuRS) is one of the aminoacyl-tRNA synthetases, which establish the genetic code table. The Protein Research Group and the University of Tokyo has determined the structures of the aminoacylation complexes for LeuRS and tRNALeu by using X-ray crystallographic analysis at the SPring-8, the synchrotron radiation facility. Researchers elucidated how LeuRS recognizes tRNALeu, thereby elucidating one of the mechanisms of the genetic code table.
  The research results were published in the online issue of Nature Structural & Molecular Biology.