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10 Years at GSC (Genomic Sciences Center)

Elucidation of molecular mechanism for intracellular tumor necrosis factor (TNF) signaling



The Protein Research Group has determined the three-dimensional structure of the CYLD protein, which plays an important role in intracellulartumor necrosis factor (TNF) signaling during immune response or inflammatory response processes in vivo. The research group has also elucidated some of the mechanisms involved in the protein interaction network. This research could be useful in understanding the mechanisms of tumor suppression and is expected to have applications in the identification of novel drug discovery targets. The research results were published in the September issueof the US scientific journal, Structure.