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10 Years at GSC (Genomic Sciences Center)

High-resolution Analysis of the Movement of Protein on Genome

The Human Genome Research Group has announced that it has succeeded in grasping the movement of protein on the genome with a resolution about 10,000-fold that of the conventional method.
  A joint research group from the Human Genome Research Group and the U.K. Cancer Institute developed, last year, a new technology “CHIP-chip method,” which examines the behavior and replication region of protein on the chromosome. This time, the research group upgraded this technology and analyzed the movement of the protein called “cohesion” (chromosome adhesion gene). Cohesin plays an important role in cell division, but how it combined on the genome was unknown.
  The research group discovered that the cohesin that combines on the gene transfers its bonding position by being repelled when other proteins (RNA synthetase etc.) have moved to this position.
This research clarified for the first time that cohesin can cleverly live with other proteins by flexibly moving around on the genome without disturbing other genome functions (like transcription), and transfer correctly the chromosome from parent cells to daughter cells.
  The research results were published in the online version of the U.K. science journal “Nature.”